The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(–/–) mice were found to be developmentally normal and reproductively fit and failed to develop any age-relat...

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Detalhes bibliográficos
Main Authors: Lindsten, Tullia, Ross, Andrea J., King, Ayala, Zong, Wei-Xing, Rathmell, Jeffrey C., Shiels, Helena A., Ulrich, Eugen, Waymire, Katrina G., Mahar, Patryce, Frauwirth, Kenneth, Chen, Yifeng, Wei, Michael, Eng, Vicki M., Adelman, David M., Simon, M. Celeste, Ma, Averil, Golden, Jeffrey A., Evan, Gerard, Korsmeyer, Stanley J., MacGregor, Grant R., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057227/
https://ncbi.nlm.nih.gov/pubmed/11163212
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