Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation

Por Olivotto, Eleonora, Otero, Miguel, Marcu, Kenneth B, Goldring, Mary B
Publicado no RMD Open (2015)

NF-κB Signaling: Multiple angles to target OA

Por Marcu, Kenneth B., Otero, Miguel, Olivotto, Eleonora, Borzi, Rosa Maria, Goldring, Mary B.
Publicado em 2010

Polyamine Depletion Inhibits NF-κB Binding to DNA and Interleukin-8 production in Human Chondrocytes Stimulated by Tumor Necrosis Factor-α

Por FACCHINI, ANNALISA, BORZÌ, ROSA MARIA, MARCU, KENNETH B., STEFANELLI, CLAUDIO, OLIVOTTO, ELEONORA, GOLDRING, MARY B., FACCHINI, ANDREA, FLAMIGNI, FLAVIO
Publicado em 2005

Sustained NF-κB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1

Por Penzo, Marianna, Massa, Paul E., Olivotto, Eleonora, Bianchi, Francesca, Borzi, Rosa Maria, Hanidu, Adedayo, Li, Xiang, Li, Jun, Marcu, Kenneth B.
Publicado em 2009

Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Ma...

Por Assirelli, Elisa, Pulsatelli, Lia, Dolzani, Paolo, Platano, Daniela, Olivotto, Eleonora, Filardo, Giuseppe, Trisolino, Giovanni, Facchini, Andrea, Borzì, Rosa Maria, Meliconi, Riccardo
Publicado em 2014

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

Por Olivotto, Eleonora, Otero, Miguel, Astolfi, Annalisa, Platano, Daniela, Facchini, Annalisa, Pagani, Stefania, Flamigni, Flavio, Facchini, Andrea, Goldring, Mary B., Borzì, Rosa Maria, Marcu, Kenneth B.
Publicado em 2013

Differential requirements for IKKα and IKKβ in the differentiation of primary human osteoarthritic chondrocytes

Por Olivotto, Eleonora, Borzi', Rosa Maria, Vitellozzi, Roberta, Pagani, Stefania, Facchini, Annalisa, Battistelli, Michela, Penzo, Marianna, Li, Xiang, Flamigni, Flavio, Li, Jun, Falcieri, Elisabetta, Facchini, Andrea, Marcu, Kenneth B
Publicado em 2008

ROLES OF INFLAMMATORY AND ANABOLIC CYTOKINES IN CARTILAGE METABOLISM: SIGNALS AND MULTIPLE EFFECTORS CONVERGE UPON MMP-13 REGULATION IN OSTEOARTHRITIS

Por Goldring, Mary B., Otero, Miguel, Plumb, Darren A., Dragomir, Cecilia, Favero, Marta, El Hachem, Karim, Hashimoto, Ko, Roach, Helmtrud I., Olivotto, Eleonora, Borzì, Rosa Maria, Marcu, Kenneth B.
Publicado em 2011

p16(INK4a) and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

Por Philipot, Didier, Guérit, David, Platano, Daniela, Chuchana, Paul, Olivotto, Eleonora, Espinoza, Francisco, Dorandeu, Anne, Pers, Yves-Marie, Piette, Jacques, Borzi, Rosa Maria, Jorgensen, Christian, Noel, Danièle, Brondello, Jean-Marc
Publicado em 2014

MMP-13 loss associated with impaired ECM remodelling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors

Por Borzi, Rosa Maria, Olivotto, Eleonora, Pagani, Stefania, Vitellozzi, Roberta, Neri, Simona, Battistelli, Michela, Falcieri, Elisabetta, Facchini, Annalisa, Flamigni, Flavio, Penzo, Marianna, Platano, Daniela, Santi, Spartaco, Facchini, Andrea, Marcu, Kenneth B
Publicado em 2010

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

Por Otero, Miguel, Plumb, Darren A., Tsuchimochi, Kaneyuki, Dragomir, Cecilia L., Hashimoto, Ko, Peng, Haibing, Olivotto, Eleonora, Bevilacqua, Michael, Tan, Lujian, Yang, Zhiyong, Zhan, Yumei, Oettgen, Peter, Li, Yefu, Marcu, Kenneth B., Goldring, Mary B.
Publicado em 2012

Inhibitor of NF-κB Kinases α and β Are Both Essential for High Mobility Group Box 1-Mediated Chemotaxis

Por Penzo, Marianna, Molteni, Raffaella, Suda, Tomomi, Samaniego, Sylvia, Raucci, Angela, Habiel, David M., Miller, Frederick, Jiang, Hui-ping, Li, Jun, Pardi, Ruggero, Palumbo, Roberta, Olivotto, Eleonora, Kew, Richard R., Bianchi, Marco E., Marcu, Kenneth B.
Publicado em 2010