MMP-13 loss associated with impaired ECM remodelling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors

PURPOSE: To link MMP-13 activity and ECM remodeling to alterations in regulatory factors leading to a disruption in chondrocyte homeostasis. METHODS: Matrix-metalloproteinase-13 (MMP-13) expression was ablated in primary human chondrocytes by stable retrotransduction of short-hairpin RNAs. The effec...

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Autors principals: Borzi, Rosa Maria, Olivotto, Eleonora, Pagani, Stefania, Vitellozzi, Roberta, Neri, Simona, Battistelli, Michela, Falcieri, Elisabetta, Facchini, Annalisa, Flamigni, Flavio, Penzo, Marianna, Platano, Daniela, Santi, Spartaco, Facchini, Andrea, Marcu, Kenneth B
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921033/
https://ncbi.nlm.nih.gov/pubmed/20506238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27512
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