IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

BACKGROUND: The non-canonical NF-κB activating kinase IKKα, encoded by CHUK (conserved-helix-loop-helix-ubiquitous-kinase), has been reported to modulate pro- or anti- inflammatory responses, cellular survival and cellular differentiation. Here, we have investigated the mechanism of action of IKKα a...

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Autors principals: Olivotto, Eleonora, Otero, Miguel, Astolfi, Annalisa, Platano, Daniela, Facchini, Annalisa, Pagani, Stefania, Flamigni, Flavio, Facchini, Andrea, Goldring, Mary B., Borzì, Rosa Maria, Marcu, Kenneth B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759388/
https://ncbi.nlm.nih.gov/pubmed/24023802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073024
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