Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis

CHUK/IKKα contributes to collagenase-driven extracellular matrix remodeling and chondrocyte hypertrophic differentiation in vitro, in a kinase-independent manner. These processes contribute to osteoarthritis (OA), where chondrocytes experience a phenotypic shift towards hypertrophy concomitant with...

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Publicat a:Sci Rep
Autors principals: Culley, Kirsty L., Lessard, Samantha G., Green, Jordan D., Quinn, Justin, Chang, Jun, Khilnani, Tyler, Wondimu, Elisabeth B., Dragomir, Cecilia L., Marcu, Kenneth B., Goldring, Mary B., Otero, Miguel
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586628/
https://ncbi.nlm.nih.gov/pubmed/31222033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45334-5
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