E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

Matrix metalloproteinase (MMP)-13 has a pivotal, rate-limiting function in cartilage remodeling and degradation due to its specificity for cleaving type II collagen. The proximal MMP13 promoter contains evolutionarily conserved E26 transformation-specific sequence binding sites that are closely flan...

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Библиографические подробности
Главные авторы: Otero, Miguel, Plumb, Darren A., Tsuchimochi, Kaneyuki, Dragomir, Cecilia L., Hashimoto, Ko, Peng, Haibing, Olivotto, Eleonora, Bevilacqua, Michael, Tan, Lujian, Yang, Zhiyong, Zhan, Yumei, Oettgen, Peter, Li, Yefu, Marcu, Kenneth B., Goldring, Mary B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271009/
https://ncbi.nlm.nih.gov/pubmed/22158614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265744
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