E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

Matrix metalloproteinase (MMP)-13 has a pivotal, rate-limiting function in cartilage remodeling and degradation due to its specificity for cleaving type II collagen. The proximal MMP13 promoter contains evolutionarily conserved E26 transformation-specific sequence binding sites that are closely flan...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Otero, Miguel, Plumb, Darren A., Tsuchimochi, Kaneyuki, Dragomir, Cecilia L., Hashimoto, Ko, Peng, Haibing, Olivotto, Eleonora, Bevilacqua, Michael, Tan, Lujian, Yang, Zhiyong, Zhan, Yumei, Oettgen, Peter, Li, Yefu, Marcu, Kenneth B., Goldring, Mary B.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
Molecular Bases of Disease
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271009/
https://ncbi.nlm.nih.gov/pubmed/22158614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265744
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