E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

Matrix metalloproteinase (MMP)-13 has a pivotal, rate-limiting function in cartilage remodeling and degradation due to its specificity for cleaving type II collagen. The proximal MMP13 promoter contains evolutionarily conserved E26 transformation-specific sequence binding sites that are closely flan...

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Hlavní autoři: Otero, Miguel, Plumb, Darren A., Tsuchimochi, Kaneyuki, Dragomir, Cecilia L., Hashimoto, Ko, Peng, Haibing, Olivotto, Eleonora, Bevilacqua, Michael, Tan, Lujian, Yang, Zhiyong, Zhan, Yumei, Oettgen, Peter, Li, Yefu, Marcu, Kenneth B., Goldring, Mary B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271009/
https://ncbi.nlm.nih.gov/pubmed/22158614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265744
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