E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

Matrix metalloproteinase (MMP)-13 has a pivotal, rate-limiting function in cartilage remodeling and degradation due to its specificity for cleaving type II collagen. The proximal MMP13 promoter contains evolutionarily conserved E26 transformation-specific sequence binding sites that are closely flan...

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Detalhes bibliográficos
Main Authors: Otero, Miguel, Plumb, Darren A., Tsuchimochi, Kaneyuki, Dragomir, Cecilia L., Hashimoto, Ko, Peng, Haibing, Olivotto, Eleonora, Bevilacqua, Michael, Tan, Lujian, Yang, Zhiyong, Zhan, Yumei, Oettgen, Peter, Li, Yefu, Marcu, Kenneth B., Goldring, Mary B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271009/
https://ncbi.nlm.nih.gov/pubmed/22158614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265744
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