ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by Inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity

AIM: We showed previously that ELF3 protein levels are increased in osteoarthritic (OA) cartilage, that ELF3 accounts for inflammatory cytokine-driven MMP13 gene expression, and that, upon induction by IL-1β, ELF3 binds to the COL2A1 promoter and suppresses its activity in chondrocytes. Here, we aim...

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Detalhes bibliográficos
Publicado no:Connect Tissue Res
Main Authors: Otero, Miguel, Peng, Haibing, El Hachem, Karim, Culley, Kirsty L., Wondimu, Elisabeth B., Quinn, Justin, Asahara, Hiroshi, Tsuchimochi, Kaneyuki, Hashimoto, Ko, Goldring, Mary B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326708/
https://ncbi.nlm.nih.gov/pubmed/27310669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03008207.2016.1200566
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