p16(INK4a) and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

INTRODUCTION: Recent evidence suggests that tissue accumulation of senescent p16(INK4a)-positive cells during the life span would be deleterious for tissue functions and could be the consequence of inherent age-associated disorders. Osteoarthritis (OA) is characterized by the accumulation of chondro...

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Detalhes bibliográficos
Main Authors: Philipot, Didier, Guérit, David, Platano, Daniela, Chuchana, Paul, Olivotto, Eleonora, Espinoza, Francisco, Dorandeu, Anne, Pers, Yves-Marie, Piette, Jacques, Borzi, Rosa Maria, Jorgensen, Christian, Noel, Danièle, Brondello, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060445/
https://ncbi.nlm.nih.gov/pubmed/24572376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4494
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