INTERSECTINg Pathways in Cell Biology

Por O'Bryan, John P.
Publicado em 2010

Pharmacological Targeting of RAS: Recent Success with Direct Inhibitors.

Por O’Bryan, John P.
Publicado no Pharmacol Res (2018)

Intersectin 1 is required for neuroblastoma tumorigenesis

Por Russo, Angela, O'Bryan, John P.
Publicado em 2012

Bimolecular Fluorescence Complementation

Por Wong, Katy A., O'Bryan, John P.
Publicado em 2011

Intersectin scaffold proteins and their role in cell signaling and endocytosis

Por Herrero-Garcia, Erika, O’Bryan., John P.
Publicado no Biochim Biophys Acta (2016)

Direct Inhibition of RAS: Quest for the Holy Grail?

Por Spencer-Smith, Russell, O’Bryan, John P.
Publicado no Semin Cancer Biol (2017)

Inhibition of RAS: proven and potential vulnerabilities

Por Zuberi, Mariyam, Khan, Imran, O’Bryan, John P.
Publicado no Biochem Soc Trans (2020)

Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

Por Hunter, Michael P., Russo, Angela, O’Bryan, John P.
Publicado em 2013

Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase

Por Okur, Mustafa Nazir, Russo, Angela, O'Bryan, John P.
Publicado em 2014

Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

Por Khan, Imran, Spencer-Smith, Russell, O’Bryan, John P.
Publicado no Oncogene (2018)

Therapeutic Targeting of RAS: New Hope for Drugging the “Undruggable”

Por Khan, Imran, Rhett, J. Matthew, O’Bryan, John P.
Publicado no Biochim Biophys Acta Mol Cell Res (2019)

Biology, Pathology, and Therapeutic Targeting of RAS

Por Rhett, J. Matthew, Khan, Imran, O’Bryan, John P.
Publicado no Adv Cancer Res (2020)

Phosphatidylinositol 3-kinase, Class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis

Por Russo, Angela, Okur, Mustafa Nazir, Bosland, Maarten, O'Bryan, John P.
Publicado no Cancer Lett (2015)

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition

Por Spencer-Smith, Russell, Li, Lie, Prasad, Sheela, Koide, Akiko, Koide, Shohei, O'Bryan, John P.
Publicado no Small GTPases (2017)

Cooperative Role of Caveolin-1 and C-Terminal Src Kinase Binding Protein in C-Terminal Src Kinase-Mediated Negative Regulation of c-Src

Por Place, Aaron T., Chen, Zhenlong, Bakhshi, Farnaz R., Liu, Guoquan, O'Bryan, John P., Minshall, Richard D.
Publicado em 2011

Cardiac-Specific Expression of the Tetracycline Transactivator Confers Increased Heart Function and Survival Following Ischemia Reperfusion Injury

Por Elsherif, Laila, Wang, Xuerong, Grachoff, Milana, Wolska, Beata M., Geenen, David L., O'Bryan, John P.
Publicado em 2012

A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation

Por Wong, Katy A., Russo, Angela, Wang, Xuerong, Chen, Yun-Ju, Lavie, Arnon, O'Bryan, John P.
Publicado em 2012

Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice

Por Harris, Jamie, Herrero-Garcia, Erika, Russo, Angela, Kajdacsy-Balla, Andre, O’Bryan, John P., Chiu, Bill
Publicado no J Pediatr Hematol Oncol (2017)

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

Por Burmeister, Brian T., Wang, Li, Gold, Matthew G., Skidgel, Randal A., O'Bryan, John P., Carnegie, Graeme K.
Publicado no J Biol Chem (2015)

Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function

Por Sudhahar, Varadarajan, Okur, Mustafa Nazir, O’Bryan, John P., Minshall, Richard D., Fulton, David, Ushio-Fukai, Masuko, Fukai, Tohru
Publicado no Am J Physiol Cell Physiol (2020)