Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function

Caveolin-1 (Cav-1) is a scaffolding protein and a major component of caveolae/lipid rafts. Previous reports have shown that endothelial dysfunction in Cav-1-deficient (Cav-1(−/−)) mice is mediated by elevated oxidative stress through endothelial nitric oxide synthase (eNOS) uncoupling and increased...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Sudhahar, Varadarajan, Okur, Mustafa Nazir, O’Bryan, John P., Minshall, Richard D., Fulton, David, Ushio-Fukai, Masuko, Fukai, Tohru
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789967/
https://ncbi.nlm.nih.gov/pubmed/32936699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00151.2020
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