Akt2 Stabilizes ATP7A, a Cu transporter for SOD3, in Vascular Smooth Muscles: Novel Mechanism to limit Endothelial Dysfunction in Type2 diabetes

OBJECTIVE: Copper (Cu) transporter ATP7A is required for full activation of extracellular SOD (SOD3), which is secreted from vascular smooth muscle cells (VSMCs) and anchors to endothelial cell surface to preserve endothelial function by scavenging extracellular superoxide. We reported that ATP7A pr...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Sudhahar, Varadarajan, Okur, Mustafa Nazir, Bagi, Zsolt, O'Bryan, John P, Hay, Nissim, Makino, Ayako, Patel, Vijay S, Phillips, Shane A, Stepp, David, Ushio-Fukai, Masuko, Fukai, Tohru
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823760/
https://ncbi.nlm.nih.gov/pubmed/29301787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309819
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