Akt2 Stabilizes ATP7A, a Cu transporter for SOD3, in Vascular Smooth Muscles: Novel Mechanism to limit Endothelial Dysfunction in Type2 diabetes

OBJECTIVE: Copper (Cu) transporter ATP7A is required for full activation of extracellular SOD (SOD3), which is secreted from vascular smooth muscle cells (VSMCs) and anchors to endothelial cell surface to preserve endothelial function by scavenging extracellular superoxide. We reported that ATP7A pr...

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Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Sudhahar, Varadarajan, Okur, Mustafa Nazir, Bagi, Zsolt, O'Bryan, John P, Hay, Nissim, Makino, Ayako, Patel, Vijay S, Phillips, Shane A, Stepp, David, Ushio-Fukai, Masuko, Fukai, Tohru
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823760/
https://ncbi.nlm.nih.gov/pubmed/29301787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309819
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