The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2

VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its role in VEGFR2 signaling and angiogenesis is entirely unknown. Here, we describe the unexpected crosstalk between the Copper transpor...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ash, Dipankar, Sudhahar, Varadarajan, Youn, Seock-Won, Okur, Mustafa Nazir, Das, Archita, O’Bryan, John P., McMenamin, Maggie, Hou, Yali, Kaplan, Jack H., Fukai, Tohru, Ushio-Fukai, Masuko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149886/
https://ncbi.nlm.nih.gov/pubmed/34035268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23408-1
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