Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

Oxidative stress and endothelial dysfunction contribute to vascular complication in diabetes. Extracellular superoxide dismutase (SOD3) is one of the key antioxidant enzymes that obtains copper via copper transporter ATP7A. SOD3 is secreted from vascular smooth muscles cells (VSMCs) and anchors at t...

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Main Authors: Sudhahar, Varadarajan, Urao, Norifumi, Oshikawa, Jin, McKinney, Ronald D., Llanos, Roxana M., Mercer, Julian F.B., Ushio-Fukai, Masuko, Fukai, Tohru
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2013
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806617/
https://ncbi.nlm.nih.gov/pubmed/23884884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1228
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