Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

Oxidative stress and endothelial dysfunction contribute to vascular complication in diabetes. Extracellular superoxide dismutase (SOD3) is one of the key antioxidant enzymes that obtains copper via copper transporter ATP7A. SOD3 is secreted from vascular smooth muscles cells (VSMCs) and anchors at t...

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Autors principals: Sudhahar, Varadarajan, Urao, Norifumi, Oshikawa, Jin, McKinney, Ronald D., Llanos, Roxana M., Mercer, Julian F.B., Ushio-Fukai, Masuko, Fukai, Tohru
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806617/
https://ncbi.nlm.nih.gov/pubmed/23884884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1228
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