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Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase

Ubiquitylation of receptor tyrosine kinases (RTKs) regulates their trafficking and lysosomal degradation. The multidomain scaffolding protein intersectin 1 (ITSN1) is an important regulator of this process. ITSN1 stimulates ubiquitylation of the epidermal growth factor receptor (EGFR) through enhanc...

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Autors principals: Okur, Mustafa Nazir, Russo, Angela, O'Bryan, John P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911288/
https://ncbi.nlm.nih.gov/pubmed/24216759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00850-13
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