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Therapeutic Targeting of RAS: New Hope for Drugging the “Undruggable”

RAS is the most frequently mutated oncogene in cancer and a critical driver of oncogenesis. Therapeutic targeting of RAS has been a goal of cancer research for more than 30 years due to its essential role in tumor formation and maintenance. Yet the quest to inhibit this challenging foe has been elus...

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Vydáno v:Biochim Biophys Acta Mol Cell Res
Hlavní autoři: Khan, Imran, Rhett, J. Matthew, O’Bryan, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937383/
https://ncbi.nlm.nih.gov/pubmed/31678118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2019.118570
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