Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure. Src homology 2 domain-containing phosphatase (Shp2) is critical for cardiac function because mutations resulting in loss of Shp2 catalytic a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Burmeister, Brian T., Wang, Li, Gold, Matthew G., Skidgel, Randal A., O'Bryan, John P., Carnegie, Graeme K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424342/
https://ncbi.nlm.nih.gov/pubmed/25802336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642983
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