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Phosphorylation of the cAMP-dependent Protein Kinase (PKA) Regulatory Subunit Modulates PKA-AKAP Interaction, Substrate Phosphorylation, and Calcium Signaling in Cardiac Cells

Subcellular compartmentalization of the cAMP-dependent protein kinase (PKA) by protein kinase A-anchoring proteins (AKAPs) facilitates local protein phosphorylation. However, little is known about how PKA targeting to AKAPs is regulated in the intact cell. PKA binds to an amphipathic helical region...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Manni, Sabrina, Mauban, Joseph H., Ward, Christopher W., Bond, Meredith
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527120/
https://ncbi.nlm.nih.gov/pubmed/18550536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802278200
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