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Phosphorylation of the cAMP-dependent Protein Kinase (PKA) Regulatory Subunit Modulates PKA-AKAP Interaction, Substrate Phosphorylation, and Calcium Signaling in Cardiac Cells

Subcellular compartmentalization of the cAMP-dependent protein kinase (PKA) by protein kinase A-anchoring proteins (AKAPs) facilitates local protein phosphorylation. However, little is known about how PKA targeting to AKAPs is regulated in the intact cell. PKA binds to an amphipathic helical region...

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Autors principals: Manni, Sabrina, Mauban, Joseph H., Ward, Christopher W., Bond, Meredith
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527120/
https://ncbi.nlm.nih.gov/pubmed/18550536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802278200
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