PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination

Type II isoforms of cyclic adenosine monophosphate (cAMP)–dependent protein kinase A (PKA-II) contain a phosphorylatable epitope within the inhibitory domain of RII subunits (pRII) with still unclear function. In vitro, RII phosphorylation occurs in the absence of cAMP, whereas staining of cells wit...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Cell Biol
Auteurs principaux: Isensee, Jörg, Kaufholz, Melanie, Knape, Matthias J., Hasenauer, Jan, Hammerich, Hanna, Gonczarowska-Jorge, Humberto, Zahedi, René P., Schwede, Frank, Herberg, Friedrich W., Hucho, Tim
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2018
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987717/
https://ncbi.nlm.nih.gov/pubmed/29615473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201708053
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