cAMP activation of PKA defines an ancient signaling mechanism

cAMP and the cAMP binding domain (CBD) constitute a ubiquitous regulatory switch that translates an extracellular signal into a biological response. The CBD contains α- and β-subdomains with cAMP binding to a phosphate binding cassette (PBC) in the β-sandwich. The major receptors for cAMP in mammali...

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Bibliographic Details
Main Authors: Das, Rahul, Esposito, Veronica, Abu-Abed, Mona, Anand, Ganesh S., Taylor, Susan S., Melacini, Giuseppe
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765484/
https://ncbi.nlm.nih.gov/pubmed/17182741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609033103
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