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Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation
Spatiotemporal control of the cAMP signaling pathway is governed by both hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis by phosphodiesterases (PDEs) (termination phase). The termination phase is initiated by PDEs actively targeting the protein kin...
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| Publicado en: | Biophys J |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5479052/ https://ncbi.nlm.nih.gov/pubmed/28636912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.045 |
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