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Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation

Spatiotemporal control of the cAMP signaling pathway is governed by both hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis by phosphodiesterases (PDEs) (termination phase). The termination phase is initiated by PDEs actively targeting the protein kin...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Tulsian, Nikhil Kumar, Krishnamurthy, Srinath, Anand, Ganesh Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479052/
https://ncbi.nlm.nih.gov/pubmed/28636912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.045
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