Cyclic AMP- and (R(p))-cAMPS-induced Conformational Changes in a Complex of the Catalytic and Regulatory (RIα) Subunits of Cyclic AMP-dependent Protein Kinase

We took a discovery approach to explore the actions of cAMP and two of its analogs, one a cAMP mimic ((S(p))-adenosine cyclic 3′:5′-monophosphorothioate ((S(p))-cAMPS)) and the other a diastereoisomeric antagonist ((R(p))-cAMPS), on a model system of the type Iα cyclic AMP-dependent protein kinase h...

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Autores principales: Anand, Ganesh S., Krishnamurthy, Srinath, Bishnoi, Tanushree, Kornev, Alexandr, Taylor, Susan S., Johnson, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957725/
https://ncbi.nlm.nih.gov/pubmed/20167947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900388-MCP200
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