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Dissecting the cAMP-inducible allosteric switch in protein kinase A RIα
The regulatory subunits of cAMP-dependent protein kinase (PKA) are the major receptors of cAMP in most eukaryotic cells. As the cyclic nucleotide binding (CNB) domains release cAMP and bind to the catalytic subunit of PKA, they undergo a major conformational change. The change is mediated by the B/C...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895245/ https://ncbi.nlm.nih.gov/pubmed/20512974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.400 |
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