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Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme
PKA holoenzymes contain two catalytic (C) and a regulatory (R) subunit dimer where the two R-subunits are linked by an N-terminal Dimerization/Docking (D/D) domain. Cooperative binding of four cAMP molecules induces major structural changes in the R-subunits that cause kinase activation. While coope...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097484/ https://ncbi.nlm.nih.gov/pubmed/21300294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.12.005 |
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