Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

PKA holoenzymes contain two catalytic (C) and a regulatory (R) subunit dimer where the two R-subunits are linked by an N-terminal Dimerization/Docking (D/D) domain. Cooperative binding of four cAMP molecules induces major structural changes in the R-subunits that cause kinase activation. While coope...

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Main Authors: Boettcher, Angela J., Wu, Jian, Kim, Choel, Yang, Jie, Bruystens, Jessica, Cheung, Nikki, Pennypacker, Juniper K., Blumenthal, Donald A., Kornev, Alexandr P., S.Taylor, Susan
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097484/
https://ncbi.nlm.nih.gov/pubmed/21300294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.12.005
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