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Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα
Close-range electrostatic interactions that form salt bridges are key components of protein stability. Here we investigate the role of these charged interactions in modulating the allosteric activation of protein kinase A (PKA) via computational and experimental mutational studies of a conserved bas...
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| 發表在: | Biochemistry |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495472/ https://ncbi.nlm.nih.gov/pubmed/28221775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01152 |
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