Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα

Close-range electrostatic interactions that form salt bridges are key components of protein stability. Here we investigate the role of these charged interactions in modulating the allosteric activation of protein kinase A (PKA) via computational and experimental mutational studies of a conserved bas...

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Gepubliceerd in:Biochemistry
Hoofdauteurs: Barros, Emília P., Malmstrom, Robert D., Nourbakhsh, Kimya, Del Rio, Jason C., Kornev, Alexandr P., Taylor, Susan S., Amaro, Rommie E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495472/
https://ncbi.nlm.nih.gov/pubmed/28221775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01152
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