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Allostery through the computational microscope: cAMP activation of a canonical signaling domain
Ligand-induced protein allostery plays a central role in modulating cellular signaling pathways. Here, using the conserved cyclic-nucleotide binding domain of protein kinase A’s (PKA) regulatory subunit as a prototype signaling unit, we combine long-timescale, all-atom molecular dynamics simulations...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4504738/ https://ncbi.nlm.nih.gov/pubmed/26145448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8588 |
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