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Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling
The second messenger molecule cAMP regulates the activation phase of the cAMP signaling pathway through high-affinity interactions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR). Phosphodiesterases (PDEs) are enzymes responsible for catalyzing hydrolysis of cAMP to...
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| Pubblicato in: | Biophys J |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576172/ https://ncbi.nlm.nih.gov/pubmed/26276689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.067 |
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