Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling

The second messenger molecule cAMP regulates the activation phase of the cAMP signaling pathway through high-affinity interactions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR). Phosphodiesterases (PDEs) are enzymes responsible for catalyzing hydrolysis of cAMP to...

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Bibliografiset tiedot
Julkaisussa:Biophys J
Päätekijät: Krishnamurthy, Srinath, Tulsian, Nikhil Kumar, Chandramohan, Arun, Anand, Ganesh S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2015
Aiheet:
Proteins and Nucleic Acids
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576172/
https://ncbi.nlm.nih.gov/pubmed/26276689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.067
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