Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling

The second messenger molecule cAMP regulates the activation phase of the cAMP signaling pathway through high-affinity interactions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (PKAR). Phosphodiesterases (PDEs) are enzymes responsible for catalyzing hydrolysis of cAMP to...

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Bibliografiska uppgifter
I publikationen:Biophys J
Huvudupphovsmän: Krishnamurthy, Srinath, Tulsian, Nikhil Kumar, Chandramohan, Arun, Anand, Ganesh S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2015
Ämnen:
Proteins and Nucleic Acids
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576172/
https://ncbi.nlm.nih.gov/pubmed/26276689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.067
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