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PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

The regulatory (R) subunit is the cAMP receptor of protein kinase A. Following cAMP binding, the inactive PKA holoenzyme complex separates into two active catalytic (C) subunits and a cAMP-bound R dimer. Thus far, only monomeric R structures have been solved, which fell short in explaining differenc...

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書誌詳細
主要な著者: Bruystens, Jessica G.H., Wu, Jian, Fortezzo, Audrey, Kornev, Alexandr P., Blumenthal, Donald K., Taylor, Susan S.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963464/
https://ncbi.nlm.nih.gov/pubmed/24316401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.10.012
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