PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

The regulatory (R) subunit is the cAMP receptor of protein kinase A. Following cAMP binding, the inactive PKA holoenzyme complex separates into two active catalytic (C) subunits and a cAMP-bound R dimer. Thus far, only monomeric R structures have been solved, which fell short in explaining differenc...

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Bibliografiska uppgifter
Huvudupphovsmän: Bruystens, Jessica G.H., Wu, Jian, Fortezzo, Audrey, Kornev, Alexandr P., Blumenthal, Donald K., Taylor, Susan S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963464/
https://ncbi.nlm.nih.gov/pubmed/24316401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.10.012
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