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Structure and Allostery of the PKA RIIβ Tetrameric Holoenzyme
In its physiological state, cyclic adenosine monophosphate (cAMP)–dependent protein kinase (PKA) is a tetramer that contains a regulatory (R) subunit dimer and two catalytic (C) subunits. We describe here the 2.3 angstrom structure of full-length tetrameric RIIβ(2):C(2) holoenzyme. This structure sh...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985767/ https://ncbi.nlm.nih.gov/pubmed/22323819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213979 |
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