Structure and Allostery of the PKA RIIβ Tetrameric Holoenzyme

In its physiological state, cyclic adenosine monophosphate (cAMP)–dependent protein kinase (PKA) is a tetramer that contains a regulatory (R) subunit dimer and two catalytic (C) subunits. We describe here the 2.3 angstrom structure of full-length tetrameric RIIβ(2):C(2) holoenzyme. This structure sh...

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Autori principali: Zhang, Ping, Smith-Nguyen, Eric V., Keshwani, Malik M., Deal, Michael S., Kornev, Alexandr P., Taylor, Susan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985767/
https://ncbi.nlm.nih.gov/pubmed/22323819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213979
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