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Novel Isoform-specific Interfaces Revealed by PKA RIIβ Holoenzyme Structures
The PKA catalytic (C) subunit is inhibited by two classes of functionally non-redundant regulatory subunits, RI and RII. Unlike RI-subunits, RII-subunits are both substrates and inhibitors. Because RIIβ knockout mice have important disease phenotypes, the RIIβ holoenzyme is a target for developing i...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435109/ https://ncbi.nlm.nih.gov/pubmed/19748511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.09.014 |
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