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Novel Isoform-specific Interfaces Revealed by PKA RIIβ Holoenzyme Structures

The PKA catalytic (C) subunit is inhibited by two classes of functionally non-redundant regulatory subunits, RI and RII. Unlike RI-subunits, RII-subunits are both substrates and inhibitors. Because RIIβ knockout mice have important disease phenotypes, the RIIβ holoenzyme is a target for developing i...

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Bibliografische gegevens
Hoofdauteurs: Brown, Simon H.J., Wu, Jian, Kim, Choel, Alberto, Kimberly, Taylor, Susan S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435109/
https://ncbi.nlm.nih.gov/pubmed/19748511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.09.014
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