Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme

To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a macromolecular complex or a “PKA signalosome.” Using the RIIβ holoenzyme as a prototype, we show how autophosphorylation/dephosphorylation of t...

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發表在:PLoS Biol
Main Authors: Zhang, Ping, Knape, Matthias J., Ahuja, Lalima G., Keshwani, Malik M., King, Charles C., Sastri, Mira, Herberg, Friedrich W., Taylor, Susan S.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497662/
https://ncbi.nlm.nih.gov/pubmed/26158466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002192
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