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PKA Type IIα Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity
The catalytic (C) subunit of cyclic adenosine monophosphate (cAMP)–dependent protein kinase (PKA) is inhibited by two classes of regulatory subunits, RI and RII. The RII subunits are substrates as well as inhibitors and do not require adenosine triphosphate (ATP) to form holoenzyme, which distinguis...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4036697/ https://ncbi.nlm.nih.gov/pubmed/17932298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1146447 |
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