Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild type PKAcα

Fibrolamellar hepatocellular carcinoma (FLHCC) is driven by J-PKAcα, a kinase fusion chimera of the J-domain of DnaJB1 with PKAcα, the catalytic subunit of Protein Kinase A (PKA). Here we report the crystal structures of the chimeric fusion RIα(2):J-PKAcα(2) holoenzyme formed by J-PKAcα and the PKA...

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Bibliografiska uppgifter
I publikationen:Structure
Huvudupphovsmän: Cao, Baohua, Lu, Tsan-Wen, Fiesco, Juliana A. Martinez, Tomasini, Michael, Fan, Lixin, Simon, Sanford M., Taylor, Susan S., Zhang, Ping
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506387/
https://ncbi.nlm.nih.gov/pubmed/30905674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.03.001
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