Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

When the J-domain of the heat shock protein DnaJB1 is fused to the catalytic (C) subunit of cAMP-dependent protein kinase (PKA), replacing exon 1, this fusion protein, J-C subunit (J-C), becomes the driver of fibrolamellar hepatocellular carcinoma (FL-HCC). Here, we use cryo-electron microscopy (cry...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Lu, Tsan-Wen, Aoto, Phillip C., Weng, Jui-Hung, Nielsen, Cole, Cash, Jennifer N., Hall, James, Zhang, Ping, Simon, Sanford M., Cianfrocco, Michael A., Taylor, Susan S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793292/
https://ncbi.nlm.nih.gov/pubmed/33370777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001018
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