An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A. Biochemical analyses of clinical samples reveal that a unique property of this fusion enzyme is the ability...

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Veröffentlicht in:eLife
Hauptverfasser: Turnham, Rigney E, Smith, F Donelson, Kenerson, Heidi L, Omar, Mitchell H, Golkowski, Martin, Garcia, Irvin, Bauer, Renay, Lau, Ho-Tak, Sullivan, Kevin M, Langeberg, Lorene K, Ong, Shao-En, Riehle, Kimberly J, Yeung, Raymond S, Scott, John D
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533061/
https://ncbi.nlm.nih.gov/pubmed/31063128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44187
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