DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is a rare liver cancer that affects adolescents and young adults. Genomic analysis of FLC has revealed a 400 kb deletion in chromosome 19 that leads to the chimeric transcript DNAJB1-PRKACA (DnaJ-PKAc), comprised of the first exon of heat shock protein 40 (DNAJB1) and e...

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Udgivet i:Dis Model Mech
Main Authors: de Oliveira, Sofia, Houseright, Ruth A., Korte, Benjamin G., Huttenlocher, Anna
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197716/
https://ncbi.nlm.nih.gov/pubmed/32102783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.042564
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