Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP

Protein kinase A (PKA) holoenzyme, comprised of a cAMP-binding regulatory (R)-subunit dimer and 2 catalytic (C)-subunits, is the master switch for cAMP-mediated signaling. Of the 4 R-subunits (RIα, RIβ, RIIα, RIIβ), RIα is most essential for regulating PKA activity in cells. Our 2 RIα(2)C(2) holoenz...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lu, Tsan-Wen, Wu, Jian, Aoto, Phillip C., Weng, Jui-Hung, Ahuja, Lalima G., Sun, Nicholas, Cheng, Cecilia Y., Zhang, Ping, Taylor, Susan S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697891/
https://ncbi.nlm.nih.gov/pubmed/31363049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906036116
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados