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An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
The spatiotemporal regulation of cAMP can generate microdomains just beneath the plasma membrane where cAMP increases are larger and more dynamic than those seen globally. Real-time measurements of cAMP using mutant cyclic nucleotide-gated ion channel biosensors, pharmacological tools and RNA interf...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1462982/ https://ncbi.nlm.nih.gov/pubmed/16642035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601113 |
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