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Targeting the α4-α5 interface of RAS results in multiple levels of inhibition
Generation of RAS-targeted therapeutics has long been considered a “holy grail” in cancer research. However, a lack of binding pockets on the surface of RAS and its picomolar affinity for guanine nucleotides have made isolation of inhibitors particularly challenging. We recently described a monobody...
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| Publicado no: | Small GTPases |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6748372/ https://ncbi.nlm.nih.gov/pubmed/28692342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2017.1333188 |
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