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Direct Inhibition of RAS: Quest for the Holy Grail?
RAS GTPases (H-, K-, and N-RAS) are the most frequently mutated oncoprotein family in human cancer. However, the relatively smooth surface architecture of RAS and its picomolar affinity for nucleotide have given rise to the assumption that RAS is an “undruggable” target. Recent advancements in drug...
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| Veröffentlicht in: | Semin Cancer Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6258355/ https://ncbi.nlm.nih.gov/pubmed/29248537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2017.12.005 |
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