Targeting the α4-α5 interface of RAS results in multiple levels of inhibition

Generation of RAS-targeted therapeutics has long been considered a “holy grail” in cancer research. However, a lack of binding pockets on the surface of RAS and its picomolar affinity for guanine nucleotides have made isolation of inhibitors particularly challenging. We recently described a monobody...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Small GTPases
Autori principali: Spencer-Smith, Russell, Li, Lie, Prasad, Sheela, Koide, Akiko, Koide, Shohei, O'Bryan, John P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Brief Report - Commissioned
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748372/
https://ncbi.nlm.nih.gov/pubmed/28692342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2017.1333188
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