Taccalonolides: Novel Microtubule Stabilizers with Clinical Potential

Por Risinger, April L., Mooberry, Susan L.
Publicado em 2009

Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel

Por Risinger, April L, Mooberry, Susan L
Publicado em 2011

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

Por Rohena, Cristina C., Mooberry, Susan L.
Publicado em 2014

Taccalonolide microtubule stabilizers

Por Li, Jing, Risinger, April L., Mooberry, Susan L.
Publicado em 2014

Microtubule Dynamics as a Target in Oncology

Por Risinger, April L., Giles, Francis J., Mooberry, Susan L.
Publicado em 2008

Hydrolysis Reactions of the Taccalonolides Reveal Structure Activity Relationships

Por Li, Jing, Peng, Jiangnan, Risinger, April L., Mooberry, Susan L.
Publicado em 2013

How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site

Por Da, Chenxiao, Mooberry, Susan L., Gupton, John T., Kellogg, Glen E.
Publicado em 2013

Synthetic Reactions with Rare Taccalonolides Reveal the Value of C-22,23 Epoxidation for Microtubule Stabilizing Potency

Por Peng, Jiangnan, Risinger, April L., Li, Jing, Mooberry, Susan L.
Publicado em 2014

Eribulin Mesylate: Mechanism of Action of a Unique Microtubule Targeting Agent

Por Dybdal-Hargreaves, Nicholas F., Risinger, April L., Mooberry, Susan L.
Publicado no Clin Cancer Res (2015)

Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time

Por RISINGER, APRIL L., DYBDAL-HARGREAVES, NICHOLAS F., MOOBERRY, SUSAN L.
Publicado no Anticancer Res (2015)

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin

Por Dybdal-Hargreaves, Nicholas F., Risinger, April L., Mooberry, Susan L.
Publicado no Oncotarget (2017)

The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability

Por Risinger, April L., Natarajan, Mohan, Thomas, Charles R., Mooberry, Susan L.
Publicado em 2011

Synthesis and Biological Activities of (R)- and (S)-N-(4-methoxy-phenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride as Potent Cytotoxic Antitubulin Ag...

Por Gangjee, Aleem, Zhao, Ying, Hamel, Ernest, Westbrook, Cara, Mooberry, Susan L.
Publicado em 2011

Amyrisins A - C, O-Prenylated Flavonoids from Amyris madrensis()

Por Peng, Jiangnan, Hartley, Rachel M., Fest, Gary A., Mooberry, Susan L.
Publicado em 2012

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer

Por Robles, Andrew J., Cai, Shengxin, Cichewicz, Robert H., Mooberry, Susan L.
Publicado no Breast Cancer Res Treat (2016)

Maximiscin Induces DNA damage, Activates DNA Damage Response Pathways and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer

Por Robles, Andrew J., Du, Lin, Cichewicz, Robert H., Mooberry, Susan L.
Publicado no J Nat Prod (2016)

Structure based drug design and in vitro metabolism study: discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent

Por Xiang, Weiguo, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Publicado no Bioorg Med Chem (2018)

Function-Oriented Synthesis: Biological Evaluation of Laulimalide Analogues Derived from a Last Step Cross Metathesis Diversification Strategy

Por Mooberry, Susan L., Hilinski, Michael K., Clark, Erin A., Wender, Paul A.
Publicado em 2008

Chemically Diverse Microtubule Stabilizing Agents Initiate Distinct Mitotic Defects and Dysregulated Expression of Key Mitotic Kinases

Por Rohena, Cristina C., Peng, Jiangnan, Johnson, Tyler A., Crews, Phillip, Mooberry, Susan L.
Publicado em 2013

Structure activity-relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]p...

Por Gangjee, Aleem, Zhao, Ying, Raghavan, Sudhir, Rohena, Cristina, Mooberry, Susan L., Hamel, Ernest
Publicado em 2013