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Function-Oriented Synthesis: Biological Evaluation of Laulimalide Analogues Derived from a Last Step Cross Metathesis Diversification Strategy

Laulimalide is a potent microtubule stabilizing agent and a promising anticancer therapeutic lead. The identification of stable, efficacious and accessible analogues is critical to clinically exploiting this novel lead. To determine which structural features of laulimalide are required for beneficia...

Полное описание

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Библиографические подробности
Главные авторы: Mooberry, Susan L., Hilinski, Michael K., Clark, Erin A., Wender, Paul A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676913/
https://ncbi.nlm.nih.gov/pubmed/18662015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp800043n
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