Microtubule-stabilizing agents based on designed laulimalide analogues

Laulimalide is a potent, structurally unique microtubule-stabilizing agent originally isolated from the marine sponge Cacospongia mycofijiensis. Laulimalide exhibits an activity profile different from other microtubule-binding agents, notably including effectiveness against paclitaxel-resistant cell...

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Bibliographic Details
Main Authors: Mooberry, Susan L., Randall-Hlubek, Deborah A., Leal, Rachel M., Hegde, Sayee G., Hubbard, Robert D., Zhang, Lei, Wender, Paul A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC423276/
https://ncbi.nlm.nih.gov/pubmed/15161976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402759101
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